Article
Activating BRAF V600E mutation in aggressive pediatric Langerhans cell histiocytosis: demonstration by allele-specific PCR/direct sequencing and immunohistochemistry.
The American journal of surgical pathology - 1 Dec 2014
Méhes Gábor, Irsai Gábor, Bedekovics Judit, Beke Lívia, Fazakas Ferenc, Rózsa Tímea, Kiss Csongor
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a rare neoplastic disease originating from cells characterized by antigen-presenting Langerhans cell phenotype. The clinical spectrum of LCH is highly variable including localized and disseminated forms mostly occurring in children. Recently, about 60% of LCHs were reported to carry the activating BRAF mutation V600E. In our retrospective study, we evaluated the occurrence...
Topics
- Adolescent
- Alleles
- Child
- Child, Preschool
- DNA Mutational Analysis
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Immunohistochemistry
- Infant