Article
Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis.
BioMed research international - 1 Jan 2020
Lombardi Mariangela, D'Ascanio Michela, Scarpino Stefania, Scozzi Davide, Giordano Marco, Costarelli Leopoldo, Raj Enrico Rathina, Mancini Rita, Cardillo Giuseppe, Cardaci Vittorio, Innammorato Marta, Vecchione Andrea, Ricci Alberto
Abstract excerpt
Despite remarkable therapeutic advances have been made in the last few decades, non-small cell lung cancer (NSCLC) is still one of the leading causes of death worldwide. Brain metastases are a common complication of a wide range of human malignancies and in particular NSCLC. Brain-derived neurotrophic factor (BDNF), binding its high-affinity tyrosine kinase B receptor, has been shown to promote cancer progression...
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