Article
EGFR mutation status in brain metastases of non-small cell lung carcinoma.
Journal of neuro-oncology - 1 Jan 2013
Burel-Vandenbos Fanny, Ambrosetti Damien, Coutts Michael, Pedeutour Florence
Abstract excerpt
Brain metastases are a frequent and grave complication of non-small cell lung carcinoma (NSCLC). The prognosis is generally poor, despite standard therapy based on surgery and radiotherapy. A degree of understanding of the molecular basis of tumors has led to the development of targeted agents with promising initial findings for the treatment of NSCLC. EGFR mutations have been identified which are associated with...
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