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Article

Role and relevance of TrkB mutations and expression in non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2011

Harada Taishi, Yatabe Yasushi, Takeshita Masafumi, Koga Takaomi, Yano Tokujiro, Wang Yisong, Giaccone Giuseppe

Abstract excerpt

PURPOSE: TrkB has been involved in poor cancer outcome. TrkB mutations have been reported in non-small cell lung cancer. In this study, we aimed at characterizing the role of three potentially sensitizing TrkB mutations previously reported in lung cancer. EXPERIMENTAL DESIGN: We characterized three activation loop mutants of TrkB (M713I, R715G, and R734C) in terms of pathway activation/phosphorylation, migration,...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Gene Expression Regulation, Enzymologic

Share to NIH 3T3 Cells

Share to Receptor, trkB

Share to Sequence Homology, Amino Acid

Share to Tumor Cells, Cultured

Source

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Identifiers

PMID: 21242122
DOI: 10.1158/1078-0432.CCR-10-3034
PMCID: PMC3086954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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