Article
Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Jun 2018
Kimura Shinichi, Harada Taishi, Ijichi Kayo, Tanaka Kentaro, Liu Renpeng, Shibahara Daisuke, Kawano Yuko, Otsubo Kohei, Yoneshima Yasuto, Iwama Eiji, Nakanishi Yoichi, Okamoto Isamu
Abstract excerpt
OBJECTIVES: TrkB is a receptor for brain-derived neurotrophic factor (BDNF) and is highly expressed in various cancers, with BDNF-TrkB signaling having been implicated in tumor progression and metastasis. The role of the BDNF-TrkB system in small cell lung cancer (SCLC), a neuroendocrine cancer, has remained unclear, however. We examined BDNF and TrkB expression in SCLC patients as well as the function of...
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