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Article

A validated lineage-derived somatic truth data set enables benchmarking in cancer genome analysis.

Communications biology - 8 Dec 2020

Shand Megan, Soto Jose, Lichtenstein Lee, Benjamin David, Farjoun Yossi, Brody Yehuda, Maruvka Yosef, Blainey Paul C, Banks Eric

Abstract excerpt

Existing cancer benchmark data sets for human sequencing data use germline variants, synthetic methods, or expensive validations, none of which are satisfactory for providing a large collection of true somatic variation across a whole genome. Here we propose a data set, Lineage derived Somatic Truth (LinST), of short somatic mutations in the HT115 colon cancer cell-line, that are validated using a known cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33293579
DOI: 10.1038/s42003-020-01460-9
PMCID: PMC7722876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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