Article
A cancer cell-line titration series for evaluating somatic classification.
BMC research notes - 26 Dec 2015
Denroche Robert E, Mullen Laura, Timms Lee, Beck Timothy, Yung Christina K, Stein Lincoln, McPherson John D, Brown Andrew M K
Abstract excerpt
BACKGROUND: Accurate detection of somatic single nucleotide variants and small insertions and deletions from DNA sequencing experiments of tumour-normal pairs is a challenging task. Tumour samples are often contaminated with normal cells confounding the available evidence for the somatic variants. Furthermore, tumours are heterogeneous so sub-clonal variants are observed at reduced allele frequencies. We present...
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