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Synth4bench: Synthetic Data Generation for Benchmarking Tumor-Only Somatic Variant Calling Algorithms

2024-03-08

Abstract excerpt

<h4>Motivation</h4> Somatic variant calling is a key activity towards identifying genomic alterations; yet, the evaluation of the respective tools remains challenging due to the scarcity of high quality ground truth datasets. To overcome this limitation, we developed synth4bench, a synthetic data generation pipeline for robust benchmarking. Using a systematic process to create distinct synthetic datasets, we thor...

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Literature Corpus work: a43fb19e-bdb9-533a-a1c8-485d6a11617d
DOI: 10.1101/2024.03.07.582313

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