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Article

A Simulator for Somatic Evolution Study Design

2022-05-02

Abstract excerpt

<h4>Motivation</h4> Somatic evolution plays a key role in development, cell differentiation, and normal aging, but also diseases such as cancer, which is now mainly thought of as a disease of genetic and epigenetic modification. Understanding mechanisms of somatic mutability — variant types and frequencies, phylogenetic structure, mutational signatures, and clonal heterogeneity — and how they can vary between cel...

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Literature Corpus work
2150f2c2-22f5-59c8-be5d-cae527a63fea
DOI
10.1101/2022.05.01.487551
Open publication

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A Simulator for Somatic Evolution Study DesignDOI 10.1101/2022.05.01.487551
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