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Article

Lrp1 Regulation of Pulmonary Function. Follow-Up of Human GWAS in Mice.

American journal of respiratory cell and molecular biology - 1 Mar 2021

Nichols Cody E, House John S, Li Huiling, Ward James M, Wyss Annah, Williams Jason G, Deterding Leesa J, Bradbury Jennifer A, Miller Laura, Zeldin Darryl C, London Stephanie J

Abstract excerpt

Human genome-wide association studies (GWASs) have identified more than 270 loci associated with pulmonary function; however, follow-up studies to determine causal genes at these loci are few. SNPs in low-density lipoprotein receptor-related protein 1 (LRP1) are associated with human pulmonary function in GWASs. Using murine models, we investigated the effect of genetic disruption of the Lrp1 gene in smooth...

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Identifiers

PMID: 33290178
DOI: 10.1165/rcmb.2019-0444OC
PMCID: PMC7909338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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