Article
Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.
EBioMedicine - 1 Sept 2016
High Monica, Cho Hye-Youn, Marzec Jacqui, Wiltshire Tim, Verhein Kirsten C, Caballero Mauricio T, Acosta Patricio L, Ciencewicki Jonathan, McCaw Zackary R, Kobzik Lester, Miller-DeGraff Laura, Gladwell Wes, Peden David B, Serra M Elina, Shi Min, Weinberg Clarice, Suzuki Oscar, Wang Xuting, Bell Douglas A, Polack Fernando P, Kleeberger Steven R
Abstract excerpt
BACKGROUND: Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear. METHODS: We infected a panel of 30 inbred strains of mice with RSV and measured changes in lung disease parameters 1 and 5days post-infection and they were used in...
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