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Article

Laminin α1 is a genetic modifier of TGF-β1–stimulated pulmonary fibrosis

19 Sept 2018

Abstract excerpt

The pathogenetic mechanisms underlying the pathologic fibrosis in diseases such as idiopathic pulmonary fibrosis (IPF) are poorly understood. To identify genetic factors affecting susceptibility to IPF, we analyzed a murine genetic model of IPF in which a profibrotic cytokine (TGF-β1) was expressed in the lungs of 10 different inbred mouse strains. Surprisingly, the extent of TGF-β1-induced lung fibrosis was...

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PMID: 30232270
DOI: 10.1172/jci.insight.99574

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