Article
Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model.
Lung - 1 Oct 2024
Li Huiling, House John S, Nichols Cody E, Gruzdev Artiom, Ward James M, Li Jian-Liang, Wyss Annah B, Haque Ezazul, Edin Matthew L, Elmore Susan A, Mahler Beth W, Degraff Laura M, Shi Min, Zeldin Darryl C, London Stephanie J
Abstract excerpt
PURPOSE: Over 550 loci have been associated with human pulmonary function in genome-wide association studies (GWAS); however, the causal role of most remains uncertain. Single nucleotide polymorphisms in a disintegrin and metalloprotease domain 19 (ADAM19) are consistently related to pulmonary function in GWAS. Thus, we used a mouse model to investigate the causal link between Adam19 and pulmonary function....
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