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Article

FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema.

American journal of respiratory and critical care medicine - 15 Apr 2020

Henkel Matthew, Partyka Jessica, Gregory Alyssa D, Forno Erick, Cho Michael H, Eddens Taylor, Tout Andrew R, Salamacha Nathan, Horne William, Rao Krithika S, Wu Yijen, Alcorn John F, Kostka Dennis, Hirsch Raphael, Celedón Juan C, Shapiro Steven D, Kolls Jay K, Campfield Brian T

Abstract excerpt

Rationale: The role of FSTL-1 (follistatin-like 1) in lung homeostasis is unknown.Objectives: We aimed to define the impact of FSTL-1 attenuation on lung structure and function and to identify FSTL-1-regulated transcriptional pathways in the lung. Further, we aimed to analyze the association of FSTL-1 SNPs with lung disease.Methods: FSTL-1 hypomorphic (FSTL-1 Hypo) mice underwent lung morphometry, pulmonary...

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Identifiers

PMID: 31834999
DOI: 10.1164/rccm.201905-0973OC
PMCID: PMC7159415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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