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Germline transmission of donor, maternal and paternal mtDNA in primates

20 Oct 2020

Abstract excerpt

STUDY QUESTION: What are the long-term developmental, reproductive and genetic consequences of mitochondrial replacement therapy (MRT) in primates? SUMMARY ANSWER: Longitudinal investigation of MRT rhesus macaques (Macaca mulatta) generated with donor mtDNA that is exceedingly distant from the original maternal counterpart suggest that their growth, general health and fertility is unremarkable and similar to...

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PMID: 33289786
DOI: 10.1093/humrep/deaa308

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