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Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality

3 Nov 2020

Abstract excerpt

BACKGROUND: Pathogenic mitochondrial (mt)DNA mutations, which often cause life-threatening disorders, are maternally inherited via the cytoplasm of oocytes. Mitochondrial replacement therapy (MRT) is expected to prevent second-generation transmission of mtDNA mutations. However, MRT may affect the function of respiratory chain complexes comprised of both nuclear and mitochondrial proteins. METHODS: Based on the...

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PMID: 33488283
DOI: 10.1002/rmb2.12356

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