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Article

Mitochondrial gene replacement in primate offspring and embryonic stem cells.

Nature - 17 Sept 2009

Tachibana Masahito, Sparman Michelle, Sritanaudomchai Hathaitip, Ma Hong, Clepper Lisa, Woodward Joy, Li Ying, Ramsey Cathy, Kolotushkina Olena, Mitalipov Shoukhrat

Abstract excerpt

Mitochondria are found in all eukaryotic cells and contain their own genome (mitochondrial DNA or mtDNA). Unlike the nuclear genome, which is derived from both the egg and sperm at fertilization, the mtDNA in the embryo is derived almost exclusively from the egg; that is, it is of maternal origin. Mutations in mtDNA contribute to a diverse range of currently incurable human diseases and disorders. To establish...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19710649
DOI: 10.1038/nature08368
PMCID: PMC2774772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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