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Paternal Mitochondrial DNA Transmission During Nonhuman Primate Nuclear Transfer

1 Jun 2004

Abstract excerpt

Offspring produced by nuclear transfer (NT) have identical nuclear DNA (nDNA). However, mitochondrial DNA (mtDNA) inheritance could vary considerably. In sheep, homoplasmy is maintained since mtDNA is transmitted from the oocyte (recipient) only. In contrast, cattle are heteroplasmic, harboring a predominance of recipient mtDNA along with varying levels of donor mtDNA. We show that the two nonhuman primate Macaca...

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PMID: 15238538
DOI: 10.1534/genetics.103.025049

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