Article
The consequences of nuclear transfer for mammalian foetal development and offspring survival. A mitochondrial DNA perspective.
Reproduction (Cambridge, England) - 1 Jun 2004
St John Justin C, Lloyd Rhiannon E I, Bowles Emma J, Thomas Emma C, El Shourbagy Shahinaz
Abstract excerpt
The introduction of nuclear transfer (NT) and other technologies that involve embryo reconstruction require us to reinvestigate patterns of mitochondrial DNA (mtDNA) transmission, transcription and replication. MtDNA is a 16.6 kb genome located within each mitochondrion. The number of mitochondria and mtDNA copies per organelle is specific to each cell type. MtDNA is normally transmitted through the oocyte to the...
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