Article
Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.
Nature - 8 Dec 2016
Kang Eunju, Wu Jun, Gutierrez Nuria Marti, Koski Amy, Tippner-Hedges Rebecca, Agaronyan Karen, Platero-Luengo Aida, Martinez-Redondo Paloma, Ma Hong, Lee Yeonmi, Hayama Tomonari, Van Dyken Crystal, Wang Xinjian, Luo Shiyu, Ahmed Riffat, Li Ying, Ji Dongmei, Kayali Refik, Cinnioglu Cengiz, Olson Susan, Jensen Jeffrey, Battaglia David, Lee David, Wu Diana, Huang Taosheng, Wolf Don P, Temiakov Dmitry, Belmonte Juan Carlos Izpisua, Amato Paula, Mitalipov Shoukhrat
Abstract excerpt
Maternally inherited mitochondrial (mt)DNA mutations can cause fatal or severely debilitating syndromes in children, with disease severity dependent on the specific gene mutation and the ratio of mutant to wild-type mtDNA (heteroplasmy) in each cell and tissue. Pathogenic mtDNA mutations are relatively common, with an estimated 778 affected children born each year in the United States. Mitochondrial replacement...
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