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Article

Distinct Clinicopathological Patterns of Mismatch Repair Status in Colorectal Cancer Stratified by KRAS Mutations.

PloS one - 1 Jan 2015

Li Wenbin, Zhi Wenxue, Zou Shuangmei, Qiu Tian, Ling Yun, Shan Ling, Shi Susheng, Ying Jianming

Abstract excerpt

In sporadic colorectal cancer (CRC), the BRAFV600E mutation is associated with deficient mismatch repair (MMR) status and inversely associated with to KRAS mutations. In contrast to deficient MMR (dMMR) CRC, data on the presence of KRAS oncogenic mutations in proficient MMR (pMMR) CRC and their relationship with tumor progression are scarce. We therefore examined the MMR status in combination with KRAS mutations...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to Logistic Models

Share to Multivariate Analysis

Share to MutL Protein Homolog 1

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 26042813
DOI: 10.1371/journal.pone.0128202
PMCID: PMC4456280

Genes

KRAS
MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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