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Article

Immunohistochemical expression pattern of MMR protein can specifically identify patients with colorectal cancer microsatellite instability.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jul 2014

Amira Arfaoui Toumi, Mouna Trabelsi, Ahlem Blel, Raoudha Aloui, Majid Ben Hmida, Amel Hamza, Rachida Zermani, Nadia Kourdaa

Abstract excerpt

The microsatellite instability (MSI) pathway is found in most cases of hereditary nonpolyposis colorectal cancer (HNPCC) and in 12 % of sporadic colorectal cancer (CRC). It involves inactivation of deoxyribonucleic acid mismatch repair (MMR) genes MLH1, MSH2, PMS2, and MSH6. MMR germline mutation detections are an important supplement to HNPCC clinical diagnosis. It enables at-risk and mutation-positive relatives...

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Source

Identifiers

PMID: 24643686
DOI: 10.1007/s13277-014-1831-2

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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