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Article

Structures of the Wild-Type and S59L Mutant CHCHD10 Proteins Important in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia.

ACS chemical neuroscience - 20 Apr 2022

Alici Hakan, Uversky Vladimir N, Kang David E, Woo Junga Alexa, Coskuner-Weber Orkid

Abstract excerpt

The S59L genetic mutation of the mitochondrial coiled-coil-helix-coiled-coil-helix domain-containing protein 10 (CHCHD10) is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The wild-type and mutant forms of this protein contain intrinsically disordered regions, and their structural characterization has been facing challenges. Here, for the first time in the...

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Identifiers

PMID: 35349255
DOI: 10.1021/acschemneuro.2c00011

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