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Article

Holding but not folding: How a single charge flip uncouples the DNAJC7-Hsp70 relay in amyotrophic lateral sclerosis.

The FEBS journal - 1 Jun 2026

Chiang Tsung-Sheng, Boisbouvier Jerome, Gandy Lauren A

Abstract excerpt

Genetic mutations impact protein function through various routes: Some catalyze new oncogenic activities, while others trigger complete structural collapse. However, the E425K mutation in DNAJC7, associated with Amyotrophic Lateral Sclerosis (ALS), presents a far more subtle and intriguing case. In their recent study in The FEBS Journal, Elmaleh et al. (2026) FEBS Lett employed high-resolution NMR to demonstrate...

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Identifiers

PMID: 41728998
DOI: 10.1111/febs.70472
PMCID: PMC13278352

Genes

DNAJC7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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