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Article

Targeting progesterone signaling prevents metastatic ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2020

Kim Olga, Park Eun Young, Kwon Sun Young, Shin Sojin, Emerson Robert E, Shin Yong-Hyun, DeMayo Francesco J, Lydon John P, Coffey Donna M, Hawkins Shannon M, Quilliam Lawrence A, Cheon Dong-Joo, Fernández Facundo M, Nephew Kenneth P, Karpf Adam R, Widschwendter Martin, Sood Anil K, Bast Robert C, Godwin Andrew K, Miller Kathy D, Cho Chi-Heum, Kim Jaeyeon

Abstract excerpt

Effective cancer prevention requires the discovery and intervention of a factor critical to cancer development. Here we show that ovarian progesterone is a crucial endogenous factor inducing the development of primary tumors progressing to metastatic ovarian cancer in a mouse model of high-grade serous carcinoma (HGSC), the most common and deadliest ovarian cancer type. Blocking progesterone signaling by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33262282
DOI: 10.1073/pnas.2013595117
PMCID: PMC7749341

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