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Article

KRAS mutation coupled with p53 loss is sufficient to induce ovarian carcinosarcomas in mice.

International journal of cancer - 15 Apr 2017

Tang Feng-Hsiang, Hsieh Tsung-Hua, Hsu Chia-Yi, Lin Hsiao-Yun, Long Cheng-Yu, Cheng Kuang-Hung, Tsai Eing-Mei

Abstract excerpt

Ovarian carcinosarcoma cancer is the most lethal form of gynecological malignancy, but the pathogenesis and biological function for this ovarian cancer remain unknown. We establishment the transgenic mouse model of K-rasG12D p53loxP/loxP and found that K-ras mutation and p53 deletion within the ovarian surface epithelium gave rise to ovarian lesions with a hyperproliferation and endometrioid glandular morphology....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cell Transformation, Neoplastic

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Share to Proto-Oncogene Proteins p21(ras)

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Source

Identifiers

PMID: 28032649
DOI: 10.1002/ijc.30591

Genes

KRAS

Provenance

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