Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer

Abstract excerpt

Abstract Tumor-suppressor genes (TSG) are often deleted or transcriptionally suppressed in cancer. PGR codes for progesterone receptor (PR), a transcription factor whose function depends on its ligand. Although PR expression is often undetectable in cervical cancer, its relevance to the endocrine-related etiology of this prevalent gynecological disease remains unclear. In this study, we show that the deletion of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cervical Cancer and HPV Research
• Share to Cytokine Signaling Pathways and Interactions
• Share to Estrogen and related hormone effects