Article
17beta-estradiol accelerates tumor onset and decreases survival in a transgenic mouse model of ovarian cancer.
Endocrinology - 1 Mar 2010
Laviolette Laura A, Garson Kenneth, Macdonald Elizabeth A, Senterman Mary K, Courville Kerri, Crane Colleen A, Vanderhyden Barbara C
Abstract excerpt
Epithelial ovarian cancer is thought to be derived from the ovarian surface epithelium (OSE) but often goes undetected in the early stages, and as a result, the factors that contribute to its initiation and progression remain poorly understood. Epidemiological studies have suggested that the female steroid hormones are involved in ovarian carcinogenesis and that women who use hormone replacement therapy are at...
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