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Article

Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist.

Science (New York, N.Y.) - 1 Dec 2006

Poole Aleksandra Jovanovic, Li Ying, Kim Yoon, Lin Suh-Chin J, Lee Wen-Hwa, Lee Eva Y-H P

Abstract excerpt

Women with mutations in the breast cancer susceptibility gene BRCA1 are predisposed to breast and ovarian cancers. Why the BRCA1 protein suppresses tumor development specifically in ovarian hormone-sensitive tissues remains unclear. We demonstrate that mammary glands of nulliparous Brca1/p53-defi...

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Source

Identifiers

PMID: 17138902
DOI: 10.1126/science.1130471

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17138902-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist.PMID 17138902Read ↗

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.Semantic proximity Read ↗

Proliferation and ovarian hormone signaling are impaired in normal breast tissues from women with BRCA1 mutations: benefit of a progesterone receptor modulator treatment as a breast cancer preventive strategy in women with inherited BRCA1 mutations.Semantic proximity Read ↗

MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development.Semantic proximity Read ↗

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