Changing genetic profiles of Plasmodium falciparum piperaquine resistance in Southeast Asia over 25 years.

doi:10.1128/aac.01117-25

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Changing genetic profiles of Plasmodium falciparum piperaquine resistance in Southeast Asia over 25 years.

Antimicrobial agents and chemotherapy - 1 Apr 2026

Srisutham Suttipat, Suwannasin Kanokon, Saejeng Aungkana, Khantikul Nardlada, Sugaram Rungniran, Phyo Aung Pyae, Proux Stephane, Pongvongsa Tiengkham, Nguon Chea, Tripura Rupam, Chau Nguyen Hoang, Lek Dysoley, Dang Trung Nghia Ho, Peto Thomas J, Callery James J, van der Pluijm Rob W, Amaratunga Chanaki, Dhorda Mehul, von Seidlein Lorenz, Mayxay Mayfong, Thuy-Nhien Nguyen Thanh, Newton Paul N, Day Nicholas P J, Ashley Elizabeth A, Nosten Francois H, Smithuis Frank M, White Nicholas J, Dondorp Arjen M, Imwong Mallika

Abstract excerpt

Piperaquine resistance in Plasmodium falciparum has emerged in Southeast Asia and is strongly associated with mutations in the pfcrt gene and amplification of pfplasmepsin2/3. This study assessed the frequency of pfcrt mutations and pfplasmepsin2/3 gene amplifications across Southeast Asia over 25 years, which is critical for tracking resistant parasites. A total of 898 P. falciparum isolates collected from...

Topics

Plasmodium falciparum
Quinolines
Piperazines
Drug Resistance
Protozoan Proteins
Antimalarials
Aspartic Acid Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Humans

Membrane Transport Proteins

Asia, Southeastern

Malaria, Falciparum

Microsatellite Repeats

Vietnam

Source

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Identifiers

PMID: 41700869
DOI: 10.1128/aac.01117-25
PMCID: PMC13041312

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