Article
Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility.
Nature communications - 30 Dec 2024
Ibrahim Amy, Mohring Franziska, Manko Emilia, van Schalkwyk Donelly A, Phelan Jody E, Nolder Debbie, Borrmann Steffen, Adegnika Ayola A, Di Santi Silvia Maria, Alam Mohammad Shafiul, Mondal Dinesh, Nosten Francois, Sutherland Colin J, Moon Robert W, Clark Taane G, Campino Susana
Abstract excerpt
Plasmodium malariae parasites are widely observed across the tropics and sub-tropics. This slow-growing species, known to maintain chronic asymptomatic infections, has been associated with reduced antimalarial susceptibility. We analyse 251 P. malariae genomes from 28 countries, and leveraging 131,601 high-quality SNPs, demonstrate segregation of African and Asian isolates. Signals of recent evolutionary...
Topics
Join the communities discussing this publication.