Article
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.
Cell - 10 Dec 2020
Chen Carol C L, Deshmukh Shriya, Jessa Selin, Hadjadj Djihad, Lisi Véronique, Andrade Augusto Faria, Faury Damien, Jawhar Wajih, Dali Rola, Suzuki Hiromichi, Pathania Manav, A Deli, Dubois Frank, Woodward Eleanor, Hébert Steven, Coutelier Marie, Karamchandani Jason, Albrecht Steffen, Brandner Sebastian, De Jay Nicolas, Gayden Tenzin, Bajic Andrea, Harutyunyan Ashot S, Marchione Dylan M, Mikael Leonie G, Juretic Nikoleta, Zeinieh Michele, Russo Caterina, Maestro Nicola, Bassenden Angelia V, Hauser Peter, Virga József, Bognar Laszlo, Klekner Almos, Zapotocky Michal, Vicha Ales, Krskova Lenka, Vanova Katerina, Zamecnik Josef, Sumerauer David, Ekert Paul G, Ziegler David S, Ellezam Benjamin, Filbin Mariella G, Blanchette Mathieu, Hansford Jordan R, Khuong-Quang Dong-Anh, Berghuis Albert M, Weil Alexander G, Garcia Benjamin A, Garzia Livia, Mack Stephen C, Beroukhim Rameen, Ligon Keith L, Taylor Michael D, Bandopadhayay Pratiti, Kramm Christoph, Pfister Stefan M, Korshunov Andrey, Sturm Dominik, Jones David T W, Salomoni Paolo, Kleinman Claudia L, Jabado Nada
Abstract excerpt
Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here we show that 50% of G34R/V tumors (n = 95) bear activating PDGFRA mutations that display strong selection pressure at recurrence. Although considered gliomas, G34R/V tumors actually arise in GSX2/DLX-expressing...
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