Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.

doi:10.1038/s41467-020-19891-7

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Article

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.

Nature communications - 30 Nov 2020

Oladunni Fatai S, Park Jun-Gyu, Pino Paula A, Gonzalez Olga, Akhter Anwari, Allué-Guardia Anna, Olmo-Fontánez Angélica, Gautam Shalini, Garcia-Vilanova Andreu, Ye Chengjin, Chiem Kevin, Headley Colwyn, Dwivedi Varun, Parodi Laura M, Alfson Kendra J, Staples Hilary M, Schami Alyssa, Garcia Juan I, Whigham Alison, Platt Roy Neal, Gazi Michal, Martinez Jesse, Chuba Colin, Earley Stephanie, Rodriguez Oscar H, Mdaki Stephanie Davis, Kavelish Katrina N, Escalona Renee, Hallam Cory R A, Christie Corbett, Patterson Jean L, Anderson Tim J C, Carrion Ricardo, Dick Edward J, Hall-Ursone Shannan, Schlesinger Larry S, Alvarez Xavier, Kaushal Deepak, Giavedoni Luis D, Turner Joanne, Martinez-Sobrido Luis, Torrelles Jordi B

Abstract excerpt

Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18 hACE2) represent a susceptible rodent model. K18 hACE2 transgenic mice succumbed to SARS-CoV-2 infection by day 6, with virus detected in lung airway...

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Identifiers

PMID: 33257679
DOI: 10.1038/s41467-020-19891-7
PMCID: PMC7705712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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