Article

Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

2021-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Animal models recapitulating distinctive features of severe COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model of SARS-CoV-2 infection. The precise mechanisms of lethality in this mouse model remain unclear. Here, we evaluated...

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Literature Corpus work: 02479d25-423d-5f9a-8ca6-73e8cd95ec4f
DOI: 10.1101/2021.01.13.425144

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