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Article

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.

Nature - 25 Jan 2018

Chen Gaozhi, Liu Yang, Goetz Regina, Fu Lili, Jayaraman Seetharaman, Hu Ming-Chang, Moe Orson W, Liang Guang, Li Xiaokun, Mohammadi Moosa

Abstract excerpt

The ageing suppressor α-klotho binds to the fibroblast growth factor receptor (FGFR). This commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and vitamin D homeostasis. The role and mechanism of this co-receptor are unknown. Here we present the atomic structure of a 1:1:1 ternary complex that consists of the shed extracellular domain of α-klotho, the FGFR1c ligand-binding domain, and...

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Source

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Identifiers

PMID: 29342138
DOI: 10.1038/nature25451
PMCID: PMC6007875

Genes

FGF23

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