Article

Chronically elevated FGF23 drives sustained renal ERK signaling and inflammatory transcriptional programs mitigated by cFGF23 gene therapy

2024-01-20

Abstract excerpt

<h4>ABSTRACT</h4> Fibroblast growth factor 23 (FGF23) levels are highly elevated in patients with chronic kidney disease (CKD); however, whether it serves merely as a biomarker or actively contributes to kidney inflammation remains unclear. Full-length FGF23 is cleaved into C-terminal FGF23 (cFGF23), which acts as a natural antagonist of FGF23 by inhibiting its binding to the FGF receptor (FGFR) and the co-recept...

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Literature Corpus work: e286c467-976e-53e1-8b89-4e042708b5e0
DOI: 10.1101/2024.01.18.576116

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