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Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease

23 Aug 2010

Abstract excerpt

Fibroblast growth factors (Fgfs) are proteins with diverse functions in development, repair, and metabolism. The human Fgf gene family with 22 members can be classified into three groups, canonical, intracellular, and hormone-like Fgf genes. In contrast to canonical and intracellular Fgfs identified in invertebrates and vertebrates, hormone-like Fgfs, Fgf15/19, Fgf21, and Fgf23, are vertebrate-specific. The...

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PMID: 20730630
DOI: 10.1007/s00441-010-1024-2

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