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Article

Different roles of N- and C- termini in the functional activity of FGF21.

Journal of cellular physiology - 1 May 2009

Micanovic Radmila, Raches David W, Dunbar James D, Driver David A, Bina Holly A, Dickinson Craig D, Kharitonenkov Alexei

Abstract excerpt

Fibroblast growth factor 21 is a member of endocrine FGFs subfamily, along with FGF19 and FGF23. It is emerging as a novel regulator with beneficial effects on a variety of metabolic parameters, including glucose and lipid control. FGF21 activity depends on membrane protein betaKlotho that physically complexes with various FGF receptors, thus conferring them the ability to bind FGF21 and activate downstream...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19117008
DOI: 10.1002/jcp.21675

Genes

FGF21
FGF19
FGF23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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