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Article

The Klotho gene family and the endocrine fibroblast growth factors

11 Jun 2008

Abstract excerpt

PURPOSE OF REVIEW: This review summarizes recent progress in understanding of Klotho and betaKlotho function in the regulation of tissue-specific metabolic activity of the endocrine fibroblast growth factors (FGF19, FGF21, and FGF23). RECENT FINDINGS: The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the...

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PMID: 18660672
DOI: 10.1097/mnh.0b013e3282ffd994

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