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Article

The Health Impact of MAFLD, a Novel Disease Cluster of NAFLD, Is Amplified by the Integrated Effect of Fatty Liver Disease-Related Genetic Variants.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Apr 2022

Liu Zhenqiu, Suo Chen, Shi Oumin, Lin Chunqing, Zhao Renjia, Yuan Huangbo, Jin Li, Zhang Tiejun, Chen Xingdong

Abstract excerpt

BACKGROUND & AIMS: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly proposed disease category that derived from non-alcoholic fatty liver disease. The impact of MAFLD on health events has not been investigated. METHODS: UK Biobank participants were diagnosed for whether MAFLD presented at baseline. Five genetic variants (PNPLA3 rs738409 C/G, TM6SF2 rs58542926 C/T, GCKR rs1260326 T/C, MBOAT7...

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PMID: 33387670
DOI: 10.1016/j.cgh.2020.12.033

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