Article
Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy.
Scientific reports - 27 Feb 2018
Di Costanzo Alessia, Belardinilli Francesca, Bailetti Diego, Sponziello Marialuisa, D'Erasmo Laura, Polimeni Licia, Baratta Francesco, Pastori Daniele, Ceci Fabrizio, Montali Anna, Girelli Gabriella, De Masi Bruna, Angeloni Antonio, Giannini Giuseppe, Del Ben Maria, Angelico Francesco, Arca Marcello
Abstract excerpt
NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2 genes were resequenced by next generation sequencing in a cohort of 218 NAFLD subjects and 227 controls, where PNPLA3 rs738409 and MBOAT7 rs641738 genotypes were also...
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