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Aromatase (CYP19A1) gene variants, sex steroid levels, and late-life depression.

Depression and anxiety - 1 Feb 2020

Ancelin Marie-Laure, Norton Joanna, Canonico Marianne, Scarabin Pierre-Yves, Ritchie Karen, Ryan Joanne

Abstract excerpt

BACKGROUND: Sex differences in psychiatric disorders are common and could involve sex steroids. Aromatase, the product of the CYP19A1 gene, is the key enzyme in the conversion of androgen to estrogen. Whether CYP19A1 variants could be associated with depression differently in men and women has not been examined. METHODS: This population-based study included 405 men and 602 women aged ≥65 years. A clinical level...

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PMID: 31730745
DOI: 10.1002/da.22974

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