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Article

Internal Tandem Duplication of Exon 8 of c-kit Is Associated With Longer Total Survival in Canine Cutaneous Mast Cell Tumors.

Veterinary pathology - 1 Mar 2021

Brocks Bouvien A W, Bertram Christof A, Bartel Alexander, Kirpensteijn Jolle, Collins-Webb Alexandra, Catlin Chuck, Thaiwong Tuddow, Kiupel Matti

Abstract excerpt

Canine cutaneous mast cell tumors (ccMCTs) have a highly variable biological behavior and accurate prognostication is essential for therapeutic intervention. Internal tandem duplications (ITD) of exon 11 are the most commonly detected c-kit mutation in ccMCTs and are associated with poor prognosis and increased cellular proliferation. The prognostic value of detecting mutations in other exons of c-kit has not...

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PMID: 33231140
DOI: 10.1177/0300985820973463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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