Article
Heterogeneity of internal tandem duplications in the c-kit of dogs with multiple mast cell tumours.
The Journal of small animal practice - 1 Jul 2013
Amagai Y, Tanaka A, Matsuda A, Jung K, Oida K, Nishikawa S, Jang H, Matsuda H
Abstract excerpt
Mast cell tumours are one of the most common neoplasms in dogs. Mutations in the proto-oncogene c-kit, especially internal tandem duplications of exon 11, are considered to play a crucial role in mast cell tumourigenesis. In this report, two cases that suffered from multiple mast cell tumours containing an internal tandem duplication in the primary lesion but not in the secondary lesions are described. This...
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