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Article

Clustering of Activating Mutations in c-KIT’s Juxtamembrane Coding Region in Canine Mast Cell Neoplasms

1 Feb 1999

Abstract excerpt

The proto-oncogene c-KIT encodes a growth factor receptor, KIT, with ligand-dependent tyrosine kinase activity that is expressed by several cell types including mast cells. c-KIT juxtamembrane coding region mutations causing constitutive activation of KIT are capable of transforming cell lines and have been identified in a human mast cell line and in situ in human gastrointestinal stromal tumors, but have not...

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Identifiers

PMID: 9989791
DOI: 10.1046/j.1523-1747.1999.00488.x

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Related research

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Clustering of Activating Mutations in c-KIT’s Juxtamembrane Coding Region in Canine Mast Cell NeoplasmsPMID 9989791Read ↗

Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs.Semantic proximity Read ↗

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Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatmentSemantic proximity Read ↗

Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11.Semantic proximity Read ↗

Genetic Changes in Mastocytes and Their Significance in Mast Cell Tumor Prognosis and TreatmentSemantic proximity Read ↗

Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors.Semantic proximity Read ↗

Internal Tandem Duplication of Exon 8 of c-kit Is Associated With Longer Total Survival in Canine Cutaneous Mast Cell Tumors.Semantic proximity Read ↗

Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumorsSemantic proximity Read ↗

A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis.Semantic proximity Read ↗

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