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Article

Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs.

Veterinary pathology - 1 Sept 2002

Zemke D, Yamini B, Yuzbasiyan-Gurkan V

Abstract excerpt

Mast cell tumors are among the most commonly seen tumors of the skin in dogs and are more highly aggressive than mast cell tumors of other species. Some breeds display a markedly higher incidence of mast cell tumor development than others and appear to have some genetic predisposition. Recently, mutations have been found in canine mast cell tumor tissues and cell lines within the juxtamembrane domain of the...

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Share to Amino Acid Sequence
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Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-kit

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Source

Identifiers

PMID: 12243462
DOI: 10.1354/vp.39-5-529

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs.PMID 12243462Read ↗

Clustering of Activating Mutations in c-KIT’s Juxtamembrane Coding Region in Canine Mast Cell NeoplasmsSemantic proximity Read ↗

The Role of c-KIT in Tumorigenesis: Evaluation in Canine Cutaneous Mast Cell TumorsSemantic proximity Read ↗

A study of mutations in the c-kit gene of 32 dogs with mastocytoma.Semantic proximity Read ↗

Prevalence and importance of internal tandem duplications in exons 11 and 12 of c-kit in mast cell tumors of dogs.Semantic proximity Read ↗

c-KIT messenger RNA and protein expression and mutations in canine cutaneous mast cell tumors: correlations with post-surgical prognosis.Semantic proximity Read ↗

Internal Tandem Duplication of Exon 8 of c-kit Is Associated With Longer Total Survival in Canine Cutaneous Mast Cell Tumors.Semantic proximity Read ↗

Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kitSemantic proximity Read ↗

Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumorsSemantic proximity Read ↗

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatmentSemantic proximity Read ↗

Clinical, pathologic, and molecular characterization of a non-metastatic multicentric cutaneous mast cell tumor in a cow.Semantic proximity Read ↗

Concordance of c-kit mutational status in matched primary and metastatic cutaneous canine mast cell tumors at baseline.Semantic proximity Read ↗

Identification of additional mitochondrial DNA mutations in canine mast cell tumours.Semantic proximity Read ↗

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