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Article

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment

24 Oct 2019

Abstract excerpt

Mast cell neoplasia clinical presentation and biological behaviour vary considerably across mammalian species, ranging from a solitary benign mass to an aggressive systemic malignancy. Mutations in the KIT Proto-Oncogene Receptor Tyrosine Kinase (KIT) gene are common molecular abnormalities involved in mast cell tumorigenesis. KIT mutations often occur in dog, cat and human neoplastic mast cells and result in...

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PMID: 31650704
DOI: 10.1002/vms3.201

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