Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumors

Abstract excerpt

BACKGROUND: Mutations in the c-KIT proto-oncogene have been implicated in the progression of several neoplastic diseases, including gastrointestinal stromal tumors and mastocytosis in humans, and cutaneous mast cell tumors (MCTs) in canines. Mutations in human mastocytosis patients primarily occur in c-KIT exon 17, which encodes a portion of its kinase domain. In contrast, deletions and internal tandem...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mast cells and histamine
• Share to Veterinary Oncology Research
• Share to Veterinary Orthopedics and Neurology