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Mapping epidermal and dermal cellular senescence in human skin aging

6 Oct 2024

Abstract excerpt

Single-cell RNA sequencing and spatial transcriptomics enable unprecedented insight into cellular and molecular pathways implicated in human skin aging and regeneration. Senescent cells are individual cells that are irreversibly cell cycle arrested and can accumulate across the human lifespan due to cell-intrinsic and -extrinsic stressors. With an atlas of single-cell RNA-sequencing and spatial transcriptomics,...

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PMID: 39370688
DOI: 10.1111/acel.14358

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