Article

Connectivity Map and perturbation-based sensitivity analysis identifies MEK inhibitors as senolytics in human lung fibroblasts

2024-11-17

Abstract excerpt

Recently, the elimination of the disease-associated accumulation of senescent cells using senolytics has been shown to exert health benefits in animal studies. However, due to the heterogeneity of cell senescence and its unrecognized master regulators, drug development faces a complexity that must be handled. Bioinformatic elucidation of genes and pathways involved in senolysis and prediction of senolytic activity...

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Literature Corpus work: 839ba69f-2011-5430-bd49-c2ab8bde32cc
DOI: 10.1101/2024.11.16.623933

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